Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function
نویسندگان
چکیده
منابع مشابه
Excitation Contraction Coupling in Cardiac Muscle
It is well established that excitation contraction (EC) coupling in cardiac myocytes is mediated by the entry of calcium ions (Ca 2 ) from the bathing medium into the cell cytoplasm (Fabiato, 1985), which then triggers calcium-induced calcium release (CICR) from the sarcoplasmic reticulum (SR). More recently, it was proposed that a second, quite separate, EC-coupling process, mediated by an eff...
متن کاملCalcium in Cardiac Excitation- Contraction Coupling
gitudinal system of the SR, governing the Ca storage compartment with the highest recruitable amount of Ca in cardiac myocytes. The RyR are chemically coupled to L-type Ca channels via Ca, and a relatively small amount of Ca entering the cell via L-type Ca channels (depending on species or stimulation rate) activates a limited number of adjacent RyRs. This leads to Ca release from the SR, and a...
متن کاملCalcium and cardiac excitation-contraction coupling.
gitudinal system of the SR, governing the Ca storage compartment with the highest recruitable amount of Ca in cardiac myocytes. The RyR are chemically coupled to L-type Ca channels via Ca, and a relatively small amount of Ca entering the cell via L-type Ca channels (depending on species or stimulation rate) activates a limited number of adjacent RyRs. This leads to Ca release from the SR, and a...
متن کاملCardiac excitation-contraction coupling in the portal hypertensive rat.
Basal contractility and responses to beta-adrenoceptor activation are compromised in hearts from rats with chronic portal vein stenosis. Here we report the effect of partial ligation of the portal vein on myocardial G protein expression, beta-adrenoceptor-G protein coupling, and excitation-contraction coupling (ECC). Contractility (dT/dt) was reduced 30-50% in right and left ventricles, but the...
متن کاملSimulation of ATP metabolism in cardiac excitation-contraction coupling.
To obtain insights into the mechanisms underlying the membrane excitation and contraction of cardiac myocytes, we developed a computer model of excitation-contraction coupling (Kyoto model: Jpn. J. Physiol. 53 (2003) 105). This model was further expanded by incorporating pivotal reactions of ATP metabolism; the model of mitochondrial oxidative phosphorylation by Korzeniewski and Zoladz (Biophys...
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ژورنال
عنوان ژورنال: Chinese Medical Journal
سال: 2018
ISSN: 0366-6999
DOI: 10.4103/0366-6999.237395